摘要
目的探讨超敏C-反应蛋白与血脂联合评估冠心病危险性的临床应用价值。方法对375名健康体检者、397名冠脉造影阳性组患者和23名心肌梗死组患者的血脂和hsCRP值进行分析,计算危险系数,并对健康组、冠心病组及两性间的危险系数进行统计学分析和评估。结果不同年龄组(除30～39岁和40～49岁组外)血脂、hsCRP和危险系数均有显著差异,冠脉造影阳性患者的危险系数显著高于健康对照组,但冠脉造影阳性组间危险系数无显著差异。结论危险系数与动脉粥样硬化的程度无关,健康男女间的危险系数无显著性差异。危险系数评估标准整合了引起动脉粥样硬化的内因-血浆脂蛋白和外在表现-hsCRP两方面的实验数据,反映动脉粥样硬化的临床变化及发生冠心病的实际危险性,消除了冠心病发病危险性评估的性别差异,利于临床的应用。
Objective To investigate the value of high-sensitivity serum C-reaction protein （hsCRP） and lipid for evaluating the risk of coronary heart disease （CHD）. Methods Serum hsCRP and lipid were detected from 397 positive patients by coronary artery angiography, 23 patients with myocardial infarction and 375 healthy volunteers. The risk coefficient（RC） of CHD patients and controls, and those between male and female patients were analyzed statistically. Results There were significant differences in respects of serum lipid, hsCRP and the risk coefficient among different age teams （except 30-39 and 40-49 year teams）. The risk coefficient of the patients with CHD were much higher than that of controls. There were not significant differences of the risk coefficient among the CHD positive teams. Conclusions Advanced evaluating standard of the risk coefficient based on evaluating the CHD risk with hsCRP and lipid. The risk coefficient combines the intrinsic factors of atherosis, namely plasma lipoprotein and hsCRP. It can sufficiently reflect the clinical varieties of atherosis in theory, and incarnate the risk of CHD. It eliminates sex difference of the lab data in evaluating the CHD risk, so is more valuable in clinic.
出处
《江西医学检验》
2006年第5期409-410,479,共3页
Jiangxi Journal of Medical Laboratory Sciences
关键词
超敏C-反应蛋白
血脂分析
冠心病
动脉粥样硬化
危险系致
High-sensitivity C-reaction protein
Serum lipid
Coronary heart disease, Atherosis
Risk coefficient
