摘要
目的检测16层螺旋CT冠状动脉成像显示不同性质斑块的患者血清高敏C-反应蛋白(Hs-CRP)水平,探讨16层螺旋CT检查结合血清Hs-CRP检测,对冠状动脉斑块稳定性判别的价值。方法将60例住院冠心病患者(均经冠状动脉造影证实为冠心病),据临床诊断分为稳定型心绞痛(SAP)组24例、急性冠状动脉综合征(ACS)组36例,均行16层螺旋CT冠状动脉成像检查,根据螺旋CT值分为软斑块组24例、混合斑块组14例、硬斑块组22例,所有患者于冠状动脉造影前采血进行血清Hs-CRP测定。结果1.两个类型冠心病组斑块类型的分布存在显著性差异(P<0.05),ACS组以软斑块为主(占50%),混合斑块次之(31%);而SAP组则以硬斑块为主(占62%)。ACS组血清Hs-CRP(5.043±2.805)mg/L显著高于SAP组(2.221±1.580)mg/L(P<0.01)。2.血清Hs-CRP在不同性质斑块组存在显著性差异,软斑块组(5.485±2.921)mg/L、混合斑块组(4.768±1.829)mg/L显著高于硬斑块组(1.687±1.222)mg/L(P<0.01)。结论16层螺旋CT结合血清Hs-CRP检测对冠状动脉斑块稳定性的判别有一定临床价值。
Objective The present study was undertaken to evaluate the relationship between the stability of coronary plaque identified by 16-slice spiral computed tomography （CF） angiography and the levels of serum high sensitive C-reactive proteins （Hs-CRP） in patients with coronary heart disease （CHD）. Methods Sixty patients with CHD were confirmed by coronary angiography and divided into stable angina pectoris （SAP, n = 24） and acute coronary syndrome （ACS, n = 36） groups based on the clinic diagnosis. All patients underwent 16 slice spiral CT coronary angiography to quantify coronary plaque, and then patients were divided into soft plaque（ n =24）, mixed plaque（ n = 14） and hard plaque（ n =22） groups based on the CT scale. Blood were collected before angiography for measurement of serum Hs-CRP. Results Soft plaque and mixed plaque in the ACS group were more than in the SAP group （soft plaque： 18 vs. 6 cases, ACS vs. SAP, P〈 0.05 ; mixed plaque： 11 vs. 3 cases, ACS vs. SAP, P 〈 0.05 ） ; and hard plaque in the SAP group was more than in the ACS group （ 15 vs. 7 cases, SAP vs. ACS, P 〈 0.05 ）. Serum Hs-CRP in the ACS group （ Hs-CRP 5. 043 ± 2. 805rag/ L） were higher （P 〈 0.01 ） than in the SAP group （ Hs-CRP 2. 221 ± 1.58mg/L ）. Serum Hs-CRP in the soft plaque （ Hs-CRP 5. 485 ± 2.92mg/L） and mixed plaque （ Hs-CRP 4. 768 ± 1. 829mg/L） groups were higher （ P〈 0. 001 ） than in hard plaque group （Hs-CRP 1. 687 ± 1. 222mg/L）. Conclusion 16-slice spiral CT combining with levels of serum high sensitive C-reactive protein could be used to evaluate the stability of coronary plaques with accuracy.
出处
《中国心血管杂志》
2006年第5期338-341,共4页
Chinese Journal of Cardiovascular Medicine
关键词
16层螺旋CT
冠状动脉造影
C-反应蛋白
炎症反应
冠心病
16-slice spiral computed tomography
Coronary angiography
C-reactive protein
Inflammation
Coronary heart disease
