摘要
目的确定双香油软胶囊中两种成分组成的最佳配比,并通过整体动物实验考察双香油对异丙肾上腺素造成心肌缺血大鼠的抗心肌缺血的作用。方法传统中药苏合香和降香的有效成分苏合香油和降香油最佳配比采用均匀设计方法筛选;建立由异丙肾上腺素造成的心肌缺血大鼠模型,将实验分为模型对照组、双香油高、中、低3个剂量组及冠心苏合丸阳性药物对照组后进行药效学实验。结果双香油软胶囊中苏合香油、降香油两者在所选择剂量范围内的理论最佳配比为1.5∶1.0;抗心肌缺血药效学试验表明,双香油有显著的抗心肌缺血的作用,与模型对照组比较具有显著的差异。结论双香油软胶囊具有抗心肌缺血、抗血小板聚集、抑制血栓形成等方面的作用,对防治心肌缺血等方面具有一定的应用前景。
Objective To ascertain the optimal proportion of the two ingredients in Shuangxiangyou（ traditional Chinese medicines） soft capsules, and to investigate the effect of Shuangxinagyou on myocardial ischemia of rats induced by isoprel in the whole animal experiment. Methods The optimal proportion of levant storax oil and dalbergiae odoriferae oil, which were active ingredients of the traditional Chinese medicine styrax and dalbergiae odoriferae, was bolted by using uniform-design method; the myocardial ischemia model of rats was set up through the induction of isoprel and the above rats were divided into 5 groups, which were model control group, high dose group of Shuangxiangyou, middle dose group of Shuangxiangyou, low dose group of Shuangxiangyou, and positive control group of Muskone. Results Among the selected dosages, the theoritical optimal proportion of levant storax oil and dalbergiae odoriferae oil, which were both in the Shuangxiangyou soft capsules, was 1. 5：1. 0; the pharmacodynamics experiment indicated that the Shuangxiangyou had the significant anti-myocardial ischemia effect compared with model control group. Conclusions Shuangxiangyou soft capsules have anti-myocardial ischemia, anti-platelet aggregation and anti- thrombogenesis effects, and provide applied prospects for the prevention of myocardial ischemia etc.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2006年第10期663-667,共5页
Journal of Shenyang Pharmaceutical University
关键词
苏合香
降香
双香油软胶囊
均匀设计
抗心肌缺血
Liquidambar orientalis Mill
Dalbergia odorifera T. Chen
Shuangxiangyou soft capsules
uniform-design method
anti-myocardial ischemia
