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不稳定型心绞痛患者治疗前后外周血中PAC-1和CD62P的变化

The changes of CD62P and PAC-1 levels in peripheral blood in patients with unstable angina before and after treatment
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摘要 目的探讨血小板活化指标血小板α颗粒糖蛋白CD62P、血小板膜糖蛋白ⅡbⅢ-a复合物纤维蛋白原受体PAC-1在不稳定型心绞痛(UA)患者治疗前后的变化规律。方法采用流式细胞仪(FCM)检测58例住院UA患者外周血中CD62P、PAC-1在治疗前后的表达,同期以24例健康人为对照。结果UA组的CD62P、PAC-1表达率较对照组明显升高(P<0.01),治疗后明显降低,但仍高于对照组(P<0.05)。结论UA患者体内血小板处于高度活化状态,PAC-1、CD62P可作为冠心病发生急性事件监测的有效指标。 Objective To explore changes of platelet activating molecules including α-granule membrane glycoprotein(CD62P) and activating GP Ⅱ b-Ⅲ a( PAC-1 ) before and after treatment in patients with unstable angina. Methods CD62P and PAC-1 levels in peripheral blood of 58 cases with unstable angina were detected by flow-eytometry before and after treatment; 24 healthy persons were taken as normal control. Results The levels of CD62P, PAC-1 in patients with unstable angina were significantly higher than those in healthy persons (P 〈 0.01 ). The levels of CD62P,PAC-1 in patients with unstable angina were significantly lower after treatment than those before but still significantly higher than those in healthy persons ( P 〈 0.05 ). Conclusion Conclusion Platelets are at a state of high activation in patients with unstable angina, and CD62Pand PAC-lcan be considered as an effective index for predicting acute events of coronary atherosclerotic heart disease
作者 张芳 陈玉林
出处 《杭州师范学院学报(医学版)》 CAS 2006年第4期248-249,256,共3页 Journal of Hangzhou Teachers College :Medical Edition
关键词 不稳定型心绞痛 CD62P PAC-1 unstable angina flow-cytometry CD62P PAC-1
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