摘要
目的：探讨老年血液透析（HD）患者透析充分性与颈动脉粥样硬化（AS）的关系。方法：检测38例老年HD患者一般临床指标及C-反应蛋白（CRP）水平；同时应用高分辨彩色B超测患者颈动脉内膜-中层厚度（IMT）；按患者标准化蛋白分僻率（nPCR）水平分为nPCR≥1.0级及nPCR〈1.0组，分析两组患者临床指标及颈动脉硬化情况。结果：两组老年HD比较，nPCR≥1.0组患者白蛋白（Alb）、尿素氮（BUN）、血肌酐（Ser）显著高于nPCR〈1.0组，CRP和IMT显著低于nPCR〈1.0组；nPCR与CRP、Alb、BUN、ScrIMT显著相关（P〈0．01～0．05）。结论：老年HD患者nPCR为透析充分性、营养状况的有用指标，与炎症状态、颈动脉硬化及营养状况有关，炎症、营养不良、动脉硬化互为因果，炎症可能为中心环节。
Objective.To study the relationship between carotid atherosclerosis（AS） and extent of hemodialysis（HD） in senile patients. Methods：The common clinical indexes and C- reactive protein（CRP） in 38 senile HD patients were measured and the intra - media thickness（IMT） of extracranial common carotid artery was examined by high - resolution B - mode ultrasonography. Based on the normalized protein catabolic rate（nPCR）, these patients were divided into two groups, i.e. nPCR≥1. 0 group and nPCR〈1. 0 group. Results：Compared with those in nPCR〈. 0 group, the levels of serum albumin（Alb）, blood urea nitrogen（BUN）, serum creatinine（Ser） were significantly higher and CRP and IMT were significantly lower in nPCR≥1. 0 group. There were significant relationships between nPCR and the levels of CRP, Alb, BUN, Ser and IMT, respectively（P〈0. 01 to 0. 05）. Conclusion： nPCR is a helpful index to evaluate the extent of hemodialysis and nourished conditions in senile HD patients.
出处
《西南国防医药》
CAS
2006年第5期486-487,共2页
Medical Journal of National Defending Forces in Southwest China
关键词
血液透析
动脉粥样硬化
C-反应蛋白
标准化蛋白分僻率
老年人
hemodialysis, atherosclerosis, C- reactive protein, normalized protein catabolic rate, diagnosis, prognosis
