摘要
目的研究木香顺气丸成型工艺参数,选用合适的辅料提高溶散时限。方法采用正交试验优选成型工艺参数,利用均匀设计法选择崩解剂最佳配比。结果木香顺气丸最佳制备工艺为:药粉为细粉,羧甲基淀粉钠(CMS-Na)占1.4%,交联羧甲基纤维素钠(CCNa)占0.5%,60℃干燥。结论该工艺生产的丸外观圆整光滑、色泽均匀一致,溶散时限短,产品质量高,符合GMP要求。
Objective To investigate the parameter of technical shaping process of Muxiang Shunqi Wan and select appropriate auxiliary materials to enhance the time limit of dissolution, Method Select parameter of technical shaping process by orthogonal test and choose the best dosage of disintegrant by wen-proportioned design. Results The best preparation and technical shaping process of Muxiang Shunqi Wan is as follows： the drug powder is refined with CMS-Na 1.4%, CCNa 0.5%, 60 ℃ dry. Conclusion PiUs made by this technical process appear round and smooth, the colour and luster are equal and conformable, the dissolving time limit is short and the quality is good, therefore, they are up to the GMP requirements.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第10期57-58,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
木香顺气丸
制备工艺
溶散时限
均匀设计
Muxiang Shunqi Wan
technical process
dissolving time limit
well-proportioned design
