摘要
Objective Bromocriptine and other dopamine D2 receptor agonists can affect a range of behaviors in nonhuman primates, particularly those behaviors associated with motor and mental function, such as suppressant behaviors and hallucinatory-like behaviors in monkeys. Besides bromocriptine, the dysfunction of the rapid eye movement sleep （REM） mechanism may also contribute to hallucinations. Dissociation of wakefulness, REM, and non-REM （NREM） can cause a series of psychotic symptoms. Methods In present study, we simultaneously recorded auditory evoked potentials （AEP） from five cerebral regions in monkeys during normal and psychotomimetic states to investigate and compare state-dependent changes in AEE Results Phase reversal of peak-to-baseline amplitude of 250 ms component （PBA250） in dorsolateral prefrontal cortex was common characteristic of hallucinatory-like and REM, and that hallucinatory-like and REM shared the equivalent modulatory orderliness of the PBA250 in dorsolateral prefrontal cortex. This result suggests that hallucinatory-like and REM share an equivalent electrophysiological modulatory in dorsolateral prefrontal cortex. Conclusion Our results reveal that emergence of the N250 in dorsolateral prefrontal cortex is an exclusive marker that may help to discern whether hallucinatory-like behaviors is exhibited, which suggests that dorsolateral prefrontal cortex may be the most pivotal region for exhibition of hallucinatory-like behaviors.
目的溴隐亭及多巴胺受体D2激动剂会影响除人以外其它灵长类动物的一系列行为,特别是与运动和心理活动相关的行为,比如动物会表现出抑制性行为及幻觉样行为。除药物外,快速眼动睡眠(REM)机制的紊乱也可导致幻觉。打乱清醒、REM及非快速眼动睡眠(NREM)的规律可引起一系列精神病症状。方法当动物处于清醒,NREM和REM及药物导致的类精神病状态时,同时记录五个皮层脑区的听觉诱发电位,从而研究对比不同状态下听觉诱发电位的变化。结果在幻觉状态及REM期,前额叶背外侧皮层记录到的潜伏期为250ms的诱发电位成分出现波峰到基线的相位翻转(PBA250),说明幻觉状态及REM在前额叶背外侧皮层有类似的调节机制。结论在前额叶背外侧皮层记录到的N250可以用来判断幻觉样行为是否出现,这表明前额叶背外侧皮层可能同幻觉样行为最相关。
基金
supported by the grants from the Program of Chinese Acad emy of Sciences(No.KJCX1-07)
National Basic Research Priorities Programme of China(No.G1999054000)
Huo Yingdong Grant(No.91038)
National Natural Science Foundation of China(No.30200068)
Famous Doctors Program of Health Department of Guangdong Province(No.21)
International Collaboration Key Project from the National Natural Science Foundation of China(No.30420120048).
