摘要
50年前人们就发现了超声的增透效应,经过40年的研究对比发现低频超声(20kHz<f<100kHz)更有利于促进分子的透皮传输[1]。低频超声之所以具有较高的增透效应是因为该频段有利于空化作用的发生。发生在皮肤表面附近的惯性空化作用在低频超声增透效应中发挥主要作用。影响低频超声增透效应的既有超声因素又有非超声因素,关于超声因素的研究已比较成熟,但有关非超声因素的研究报道还很少。人们已将低频超声增透效应用于药物透皮注入,并在积极进行将低频超声增透效应用于微创透皮检测的研究。此项研究充满机遇和挑战。
The transdermal enhancement of ultrasound was discovered 50 years ago. The advantages of low-frequency ultrasound in enhancing the transdermal transport of molecule were discovered in 40 years＂ study. Because the cavitation is easier to happen in lower frequency ultrasound, the transdermal enhancement of low-frequency ultrasound is higher. The inertial cavitations near the surface of skin play important roles in the transdermal enhancement of low-frequency ultrasound. There are many studies about the effects of the parameters of ultrasound on the transdermal enhancement of low-frequency ultrasound, but there are fewer studies about the effects of other factors. The transdermal enhancement of low-frequency ultrasound has been used for transdermal drug delivery. There are many studies about the transdermal monitoring of glucose and other analytes using low-frequency ultrasound. Many opportunities and challenges lie ahead.
出处
《医疗卫生装备》
CAS
2006年第9期24-26,共3页
Chinese Medical Equipment Journal
关键词
低频超声
空化作用
超声导入
角质层
low-frequency ultrasound
cavitation
sonophoresis
stratum comeum
