期刊文献+

HLA-G与肿瘤免疫逃逸作用 被引量:1

下载PDF
导出
摘要 人白细胞抗原(human leukocyte antigen,HLA)是位于人第6号染色体短臂上的一群高度多态性的紧密连锁基因群,HLA—G属于非经典HLA—Ⅰ类分=产(HLA—Ⅰb,HLA—G、E、F),是惟一表达于母胎界面滋养层的HLA—Ⅰ类基因,参与母胎免疫耐受的形成。但是在肿瘤微环境中,肿瘤细胞产生的HLA—G可以结合NK和T细胞表面的杀伤细胞抑制受体(killing inhibitory receptor,KIR),强烈抑制T细胞和NK细胞对肿瘤靶细胞的识别、杀伤等活性,造成类似妊娠母胎界面的免疫耐受状态,形成一条新的肿瘤逃逸途径。
出处 《中国医学文摘(肿瘤学)》 2006年第3期246-248,共3页 Journal of Chinese Medical Abstracts·Oncology
  • 相关文献

参考文献12

  • 1Iman Khalil-Daher,Nathalie Rouas-Freiss,Edgardo D. Carosella,Jean B. Dausset.Human Leukocyte Antigen-G: Immunotolerant Major Histocompatibility Complex Molecule in Transplantation[J].World Journal of Surgery.2000(7) 被引量:1
  • 2E. D. Carosella,J. Dausset,N. Rouas-Freiss.Immunotolerant functions of HLA-G[J].Cellular and Molecular Life Sciences.1999(3) 被引量:1
  • 3Paul P,Cabestre F A,Le Gal F A,et al.Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies[].Cancer Research.1999 被引量:1
  • 4Geraghty DE,Koller BH,Orr HT.A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment[].Proceedings of the National Academy of Sciences of the United States of America.1987 被引量:1
  • 5Paul P,Cabestre FA,Ibrahim EC,et al.Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5,-G6, and-G7 transcripts in human transfected cells[].Human Immunology.2000 被引量:1
  • 6McMaster M T,Labrach L C,Zhou Y,et al.Human placental HLA-G expression is restricted to differentiated cytotrophoblasts[].J Immunol.1995 被引量:1
  • 7Ibrahim el C,Aractingi S,Allory Y,et al.Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype[].International Journal of Cancer.2004 被引量:1
  • 8Ibrahim E C,Guettra N,Lacombe M J,et al.Tumor-specific upregulation of the nonclassical class I HLA-G antigen expression in renal carcinoma[].Cancer Research.2001 被引量:1
  • 9Lefebvre S,Antoine M,Uzan S,et al.Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer[].Journal of Insect Pathology.2002 被引量:1
  • 10Pangault C,Le Friec G,Caulet-Maugendre S,et al.Lung macrophages and dendritic cells express HLA-G molecules in pulmonary diseases[].Human Immunology.2002 被引量:1

同被引文献6

引证文献1

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部