摘要
目的观察比较瘢痕疙瘩、正常瘢痕及正常皮肤中转化生长因子β1型受体(TGF-βRⅠ)、Smad2、3、7的表达情况,探讨以上信号传导分子在瘢痕疙瘩形成过程中的作用。方法运用免疫组化技术检测上述4种蛋白在3种不同组织44例标本中的表达,寻找其规律。结果与正常瘢痕及正常皮肤相比,瘢痕疙瘩中TGF-βRⅠ表达增强,Smad7表达减弱(P<0.05),Smad2及Smad3表达增强不显著,但在核内积聚较为明显。结论瘢痕疙瘩中TGF-βRⅠ表达增强,Smad2、3核内持久积聚及抑制性因子Smad7表达减少,可能是瘢痕疙瘩形成的重要原因。
Objective To investigate the expression of TGF-βRⅠ , Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid. Methods Immunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data. Results The expression of TGF-βRⅠ were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus. Conclusions The results indicate that over-expression of TGF-βRⅠ, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This rcseareh may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2006年第5期368-370,共3页
Chinese Journal of Plastic Surgery
基金
国家自然科学基金(30300369)
