摘要
目的:探讨VEGF(Vascular endothelial growth factor)在大肠癌中的表达及与肿瘤大小、病理分级、临床分期和预后的关系。方法:大肠癌组织蜡块50例、癌旁组织20例、正常组织20例。采用免疫组化S-P法对标本切片进行染色。结果:VEGF在癌组织中表达明显高于癌旁组织和正常组织,三者之间差异显著(P<0.05)。VEGF抗原表达与病理分级、Dukes分期呈负相关性(P<0.01)。结论:VEGF与大肠癌的发生有关,VEGF的检测可作为大肠癌预后评估的客观指标。
Objective： To investigate expression of VEGF in colorectal cancer and its clinical significance. Methods： Immunohistechemical staining S - P method was used to detect VEGF expression in normal mucous tissue （NMT） （20 cases）, in the tissue adjacent to tunlor （TAT） （20cases）and in the colorectal cancer tissue（CCT） （50cases）. Results： VEGF level in CCT was much higher than those in NMT and in TAT. There was significant difference between the three（P 〈 0.05）. There was negative correlation between VEGF expression and pathological grading and Dukes stage（P〈 0.01）. Conclusion： VEGF is associated with the growth of the colorectal cancer, VEGF could be considered as an objective predictable index for prognosis of colorectal cancer.
出处
《现代生物医学进展》
CAS
2006年第5期36-37,共2页
Progress in Modern Biomedicine
