摘要
对苏云金杆菌内外毒素混合杀虫剂的毒性进行了较系统的研究。结果表明：该杀虫剂的经口、经皮急性毒性低，其ＬＤ（５０）均大于５０００ｍｇ／ｋｇ，无明显皮肤致敏、致突变、致畸、蓄积性和生殖毒性。有轻度的皮肤刺激作用，剂量达到１０ｍｇ／ｋｇ时呈现出免疫毒性作用。建议在农药的毒理学安全性评价程序中，增设免疫毒性的评价方法。
A series of toxicological tests of the mixed pesticide of thuringiensin and spore-crystal of Bacillus thuringiensis(MPBT)were performed. The results showed that MPBT has only a very low acute toxicity and acute dermal irritation, the acute oral and dermal LD(50)for male and female rats or mice>5 000 mg/kg has a certain immunotoxicity after oral intubation 10 mg/kg MPBT for 7 days,no dermal sensitisation, mutagenicity, teratogenicity,cumulative toxicity and reproductive toxicity .According to the results,the authors suggest that immunotoxicity study must be added in toxicological procedures of safety evaluation for pesticides.
出处
《同济医科大学学报》
CSCD
北大核心
1996年第5期362-365,共4页
Acta Universitatis Medicinae Tongji
基金
国家农业部"八五"科技攻关资助
关键词
苏云金杆菌
毒素
毒性
杀虫剂
bacillus thuringiensis
pesticide
toxin
toxicology
