摘要
[目的]研究廿烷碳五烯酸(EPA)对肺腺癌细胞的抑制增殖作用.[方法]在细胞培养、动物实验及临床应用实验基础上,进行细胞凋亡、肿瘤细胞活力及急性毒性实验.[结果]EPA对肺腺癌细胞具有明显地抑制增殖作用,EPA作用后肺腺癌细胞周期的G1,S期细胞百分率明显降低,随时间的延长及剂量增大而效能增强;EPA可引起细胞凋亡;EPA作用后血清TNF-α,IL-6,IL-1水平显著降低.[结论]长期接受EPA治疗可调节机体炎症反应,提高机体免疫力,而且单剂量应用即具有抑制肿瘤细胞增殖的作用,呈时间-剂量依赖性.
OBJECTIVE To study the inhibitory effects of EPA to the adenocarcinoma of lung cell. METHODS Based on cell developing, animal test and clinic test, the cell apoptosis and cancer cell vitality and acute poison tests were used. RESULTS EPA obviously depress and kill adenocarcinoma of lung cell EPA working on adenocarcinoma of lung cell life circle, and EPA works on adenoearcinoma and the more dose EPA works on, the better effects of cell apoptosis. The levels of TNF-α, IL-6, IL-1 obviously step down than control group. CONCLUSION Long time received EPA treatment can accommodate body inflammatory reaction, not only enhance body immunity. Single dose application can suppress tumor cell growth and vitality, and it shows time and dose dependent.
出处
《延边大学医学学报》
CAS
2006年第3期180-183,共4页
Journal of Medical Science Yanbian University
基金
国家自然科学基金资助项目(30560152)
