摘要
目的探讨全氟丙烷白蛋白微球注射剂左心超声造影临床应用的可行性。方法在30例患者中,经外周静脉弹丸式注射全氟丙烷白蛋白微球,进行左心超声造影检查,观察造影剂注射前后左心室显影等级、心内膜边界增强效果和心肌显影情况。结果30例患者中只有1例患者研究者B评价左室充盈等级为2级,其余29例患者左室充盈等级均为3级。研究者A和B评价左心室可清晰识别的节段数均显著增加,研究者A由3.60±0.81增加至5.93±0.25,研究者B由3.50±0.73增加至5.87±0.35(P<0.01)。两组研究者分别评价的结果差异无显著性意义(P>0.05),造影后平均内膜边界增强率为96.6%。30例患者左室壁心肌组织均获得了满意的显影效果。结论临床经外周静脉弹丸式注射全氟丙烷白蛋白微球行左心超声造影,取得了满意的效果。
AIM： To evaluate the feasibility of clinical application of left heart contrast echocardiography with perfluoropropane-albumin microsphere. METHODS： The left heart contrast echocardiography, using intravenous bolus injection of perfluoropropane-albumin microsphere contrast agent, was performed in the 30 patients. Left heart opacification grades, numbers of border delineation segment and myocardial contrast agent perfusions were observed. Observer A and observers B evaluated the contrast effect respectively by self-comparison between pre-injection and post-injection. RESULTS： Left heart opacification grades of 1 patient is 2 grade by observers B, the others is 3 grade. The numbers of border delineation augment segment increased from 3.60±0.81 to 5.93± 0.25 and from 3.50 ± 0.73 to 5.87 ± 0.35 by observer A and observers B. Both observers considered the number of clearly recognized endocardial border segments increased significantly. The interobserver difference is not of significance （ P 〉 0.05）. The average enhancement rate of LV endocardial border was 96.6%. The myocardial contrast agent perfusions of left ventricular walls were clearly visualized in 30 patients. CONCLUSION： Clinical application of intravenous left heart contrast echocardiagraphy with perfluoropropane-albtunin microsphere is feasibility and effective.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第8期929-932,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
全氟丙烷白蛋白微球
超声造影心动图
左心
临床应用
perfluoropropane-albumin microsphere
contrast echocardiography
left heart
clinical application
