摘要
目的：评价大蒜素分别与头孢唑林或苯唑西林联合用药,对于临床分离的革兰阳性球菌,包括金黄色葡萄球菌（staphylococcus aureus）和表皮葡萄球菌（staphylococcus epidermidis）的体外联合抗菌效应.方法：采用棋盘法设计,微量肉汤稀释法测定.测定不同浓度组合的二组抗菌药物对40株临床分离的革兰阳性球菌的最低抑菌浓度,并计算FIC指数,也称部分抑菌浓度（Fractiona inhibitory concentration index）判定联合效应.FIC≤0.5 为协同作用,0.5＜FIC≤1为相加作用,1＜FIC≤2为无关作用,FIC＞2为拮抗作用.结果：大蒜素与头孢唑林或苯唑西林联合应用后,其MIC50显著降低.FIC指数分布：FIC≤0.5占55%～75%;0.5＜FIC≤1占20%～40%;1＜FIC≤2占0～5.88%;FIC＞2为0.结论：头孢唑林或苯唑西林这2种抗菌药物与大蒜素联合用药后,对革兰阳性球菌基本表现为协同作用和相加作用.
AIM： To study the in vitro interaction of Allicin combined with Cefazolin or Oxacillin against clinical isolates of staphylococcus aureus and staphylococcus epidermidis. METHODS： The protocol was designed by checkerboard method and the MICs of Allicin combined with Cefazolin or Oxacillin against the 40 strains of staphylococci spp. were determined by broth dilution method, the FIC index was calculated according to MIC results. The combined effects were confirmed by FIC index. RESULTS： The percentage of the FIC index less than 0.5, from0.5 to 1, from 1 to 2, more than 2 was 55% - 75%, 20% -40%, 0% -5.88%, 0% respectively. CONCLUSION： The results suggested that synergism and additivity of Allicin combined with Cefazolin or Oxacillin against 40 strains of staphylococci were main reaction, and there were little autonomy and no antagonism.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第8期925-928,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
