摘要
为探索眼前节碱烧伤后晶体自由基反应与组织病理学改变关系，以新西兰兔碱烧伤为实验模型，分别测定正常眼与烧伤后不同时间晶体ＭＤＡ含量与ＳＯＤ活力，并做烧伤后晶体光学观察。结果显示，烧伤后晶体ＭＤＡ含量均显著高于正常眼，ＳＯＤ活力均显著低于正常眼。组织病理学观察，晶体上皮细胞脱落，皮质呈团块凝集、空泡样及碎片样改变。提示碱烧伤性白内障形成与自由基反应有关。
ounderstandtherelationshipbetweenfreeredicalreactionandhistopathologyinlensesafteralkaliburn,usingtheNewZealandrabbitalkali-burnmodel,wedeterminedtheactivityofsuperoxidedismutase(SOD),levelofmalondialdehyde(MDA)inthelensesbeforeand3days,1weekand2weeksafteralkaliburns,respectively.Histopathologicalobservationofthelenseswasdone7daysafterburns.TheresultsshowedSODactivityafterburnswassignificantlylowerthanthatbeforeburns,andMDAlevelwassignifi-cantlyhigher.Severedamageinthelensesafterburnsoccuredunderlightmicroscope.Theresultssuggestedcataractafteralkaliburnsisrelatedtofreeredicalreactionoccuredinthelenese.
出处
《眼科研究》
CAS
CSCD
1996年第3期160-161,共2页
Chinese Ophthalmic Research
