摘要
目的:观察奈达铂联合5-氟脲嘧啶治疗晚期食管癌的疗效和不良反应。方法:晚期食管鳞癌患者24例,奈达铂80～100mg/m2,加入生理盐水500ml中静滴2h,5-氟脲嘧啶1.0g/天,静脉滴注4h以上,第1～5天。28天为1周期,连用2个周期后评价疗效。结果:全组24例均可评价疗效及不良反应,总有效率41.7%。其中初治者14例,完全缓解1例,部分缓解6例,有效率50.0%;复治者10例,部分缓解3例,有效率30.0%。中位生存时间9.4个月,1年生存率25.0%。主要不良反应为骨髓抑制,4例(16.7%)患者出现Ⅲ度血小板下降,3例(12.5%)患者出现Ⅲ～Ⅳ度白细胞降低。消化道反应轻,未发现肝肾功能损害。结论:奈达铂联合5-氟脲嘧啶治疗晚期食管癌疗效肯定,不良反应小,尤其对老年患者耐受性好,可代替顺铂作为治疗晚期食管癌的一线方案,对顺铂耐药的患者亦有一定的疗效。
Objective： To evaluate efficacy and toxic reactions of nedaplatin plus 5-fluorouracil in treatment of advanced squamous-cell carcinoma of esophagus. Methods： A total of 24 patients with advanced squamous-cell carcinoma of esophagus were selected and nedaplatin was administered at a dose of 80-100mg/m^2, with 500ml of saline by drip infusion for 2 hours on day 1, and 5-fluorouracil at a dose of 1.0g/day intravenously over 4 hours on day 1 to 5. Chemotherapy was repeatedly given every 28 days and the efficacy was evaluated after 2 cycles of administration. Results： Response and toxicity could be assessed in all the 24 patients. The overall response rate was 41.7%. In 14 patients who didn＇t receive chemotherapy previously, the response rate was 50.0% with a complete response in 1 cases and partial response in 6. In 10 patients previously treated with cisplatin and 5-fluorouracil, the response rate was 30.0% with 3 partial cases. The median survival time and one-year survival rate was 9.4 months and 25.0%, respectively. The major toxicity was myelosuppression, in which grade Ⅲ thrombocytopenia was observed in 4 patients （16.7%） and grade Ⅲ-Ⅳ neutropenia in 3 patients （12.5%）. Gastrointestinal toxicity was mild and renal or hepatic toxicity was not observed. Conclusion： The combined chemotherapy with nedaplatin and 5-fluorouracil can be considered as a first regimen in the treatment of advanced squamous-cell carcinoma of esophagus, in which nedaplatin may be a substitute of cisplatin, not only for the patients without having chemotherapy previously, but also for those resistant to cisplatin. This regimen is active and well tolerated, especially to the aged patients.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第18期1038-1040,共3页
Chinese Journal of Clinical Oncology
关键词
食管癌
化疗
奈达铂
5-氟脲嘧啶
Esophageal carcinoma, Chemotherapy, Nedaplatin,5-fluorouracil
