摘要
目的检测下肢深静脉血栓(LDVT)患者蛋白C、蛋白S、抗凝血酶Ⅲ(AT-Ⅲ)活性和D-二聚体(D-D)含量,探讨其与下肢深静脉血栓形成之间的关系。方法用法国STAGO公司全自动血凝仪测定50例LDVT患者治疗前、治疗后及30例正常对照组的蛋白C、蛋白S、AT-Ⅲ、D-D值。结果LDVT患者治疗前和治疗后组AT-Ⅲ活性与正常对照组比较,差异无统计学意义(P>0.05)。LDVT患者治疗前的蛋白C、蛋白S均显著低于正常对照组(P<0.05),而D-D显著高于正常对照组(P<0.05)。LDVT患者治疗前的蛋白C、蛋白S均显著低于治疗后组(P<0.05)。LDVT患者治疗后组蛋白C、蛋白S、D-D与正常对照组比较,差异无统计学意义(P>0.05)。结论LDVT患者血浆蛋白C、蛋白S呈消耗性降低,经治疗可逐渐恢复正常。AT-Ⅲ与LDVT患者血栓形成无关。蛋白C、蛋白S、D-D是LDVT患者诊断与治疗监测的重要指标。
Objective To detect the activity of plasma protein C（PC） ,protein S（PS） ,antithrombin HI and the concentration of D-dimer in patients with lower deep venous thrombosis（LDVT） ,and to investigate the relationship between them and lower deep venous thrombosis. Methods Clotting assays on French STAGO autoanalyzer were used to detect the activity of plasma PC,PS,AT-HI and the concentration of D-dimer in 50 patients with LDVT and 30 normal controls. The samples were collected in pre-therapy and post-therapy phase. Results There were no significant differences in the activity of AT- Ⅲ between the LDVT group and the NC group（P〉0.05）. The activity of plasma PC,PS in the pre-therapy LDVT group were significantly lower than that of the NC group（P〈0.05）,and D-dimer was significantly higher than that of the NC group（P〈0.05）. The activity of plasma PC, PS in the pre-therapy LDVT group were significantly lower than that of the post-therapy LDVT group. There were no statistical differences in PS and D-dimer between the post-therapy LDVT group and the NC group（p〉0.05）. Conclusion The activities of plasma PC,PS in patients with LDVT decrease slgnificantly,but gradually return to normal level after treatment. There is no relationship between AT-Ⅲ and thrombosis in LDVT. The detection of activity of protein C, protein S and the concentration of Ddimer would be useful in diagnosis and curative effect evaluation of lower deep vein thrombosis.
出处
《国际检验医学杂志》
CAS
2006年第9期779-780,共2页
International Journal of Laboratory Medicine
