摘要
【目的】通过孕期不同时段铅暴露,探讨孕早期、孕后期及孕全程铅暴露对大鼠妊娠结局的影响。【方法】0.025%醋酸铅对实验组孕鼠染毒,用原子吸收光谱仪测定孕期不同时段低水平铅暴露后大鼠孕末期血铅水平,统计异常分娩情况,记录仔鼠数和仔鼠体重。【结果】铅暴露组大鼠异常妊娠率增高,但各组间差异无显著性(P>0.05)。实验组孕鼠孕末期血铅水平均高于0.483μmol/L,组间差异有非常显著性(P<0.01)。实验组仔鼠体重减轻,各组间差异有非常显著性(P<0.01)。【结论】胚胎期经胎盘“染铅”,是导致子代铅蓄积的重要原因。孕期不同时段铅暴露对仔鼠生长发育产生危害。
[Objective] To investigate effects of lead exposure on pregnancy outcome, lead acetate was administrated during early gestation, late gestation and whole gestation. [Methods] The rats were orally feeded with 0. 025% lead acetate during different gestations. The lead level in maternal blood was measured by means of grathite furnace atomic absortion spectrometry at the end of pregnancy. The abnormal pregnancy and the number, body weight of rat pups were observed. [Results] The abnormal pregnant rate of rats exposed with lead was higher than that of control,but the difference was not statistical（P〈0.05）. The maternal lead in blood were higher than 0. 483μmol/L. And the maternal lead,body weight of rat pups were significantly different among the groups（P〈0.01）. [Conclusion] Lead transmitted through placenta was an important cause of lead accumulation of offspring. Lead exposure during different gestations had bad effects on growth and development of rat pups.
出处
《中国儿童保健杂志》
CAS
2006年第4期375-376,共2页
Chinese Journal of Child Health Care
关键词
大鼠
血铅水平
体重
孕期
rat
blood lead
body weight
gestation
