摘要
目的探讨CO2气腹对胃肠动力的影响及胃肠激素的调节机制。方法随机将30只实验杂种犬分为三组,分别为A组(正常对照组)、B组(CO2气腹组)、C组(O2气腹组)。三组均进行麻醉后即刻及气腹后24h、72h胃电图检查、检测5种胃肠激素,以了解不同类型气腹对胃肠动力及胃肠激素水平的不同影响。结果(1)术前三组间胃电振幅、正常慢波比值、平均频率及胃肠激素水平差异无统计学意义(P>0.05);(2)术后24h,B组和C组的胃电振幅、正常慢波比值、胃动素、胃泌素水平均低于A组,组间差异有统计学意义(P<0.01)。(3)术后72h,A组和B组相比较,各项检测项目差异无统计学意义,A组、B组分别与C组相比较,胃电振幅、正常慢波比值、胃动素、胃泌素水平均以C组为低,组间差异有统计学意义(P<0.01)。结论(1)CO2气腹和O2气腹均可引起胃电活动异常,导致胃肠动力障碍。(2)O2气腹组气腹后胃动素水平低于CO2气腹组,胃肠动力的恢复也相对慢于CO2气腹组。(3)CO2气腹后胃肠动力恢复快。(4)CO2气腹术后胃肠动力的较快恢复与胃动素、胃泌素的分泌能较快转复正常有关。
Objective In order to supply the evidence for CO2 pneumoperitioneum＇s rationality,study the effects of CO2 pneumoperitioneum on the gastrointestinal motivity and the gastrointestinal hormones＇ regulative mechanism. Methods Put 30 incross dogs into 3 groups： Group A （control group） ,Group B （CO2 pneumoperitioneum group） and Group C（O2 pneumoperitioneum group）. Observe and compare gastrointestinal hormones and Electrogastrogram（EGG） in the three groups right after anesthesia,O2 pneumoperitioneum and CO2 pneumoperitioneum,24 hours later and 72 hours later. Results The pre- operation gastric electrical amplitudes, normal ratios of slow waves, average frequencies and gastrointestinal hormones in three groups differed insignificantly （ P 〉 0.05 ）. In 24 hours after operation, the gastric electrical amplitude, normal ratios of slow waves, MOT and GAS in Group B and C were lower than those in group A,so the difference between groups were significant （ P 〈0.01）. In 72 hours after operation,there was no significant difference for the test items in Group A and B. Comparatively, in Group C the gastric electrical amplitude, normal ratios of slow wave, MOT and GAS were averagely lower than those in the other two groups, thus the difference was significantly （ P 〈0.01）. Conclusion （ 1 ） CO2 pneumoperitioneum and O2 pneumoperitioneum can both cause the abnormal gastrointestinal motivity and thus detain it. （2） In O2 pneumoperitionum the level of MOT is obviously lower than that in CO2 pneumoperitioneum group, and the gastrointestinal motivity recovered slower. （3） The gastrointestinal motivity in CO2 pneumoperitioneum group recover soonly. （4） The sooner recovery of MOT and the GAS in CO2 pneumoperitioneum is helpful to gastrointestinal motivity.
出处
《临床外科杂志》
2006年第9期575-577,共3页
Journal of Clinical Surgery
关键词
气腹
胃电图
胃肠激素
胃肠动力
pneumoperitioneum
electrogastrogram
gastrointestinal hormone
gastrointestinal motivity
