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低剂量辐射对荷瘤小鼠肝脏抗氧化酶及肿瘤组织的作用 被引量:2

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摘要 目的探讨低剂量辐射对荷瘤小鼠肝细胞抗氧化酶的影响及合并大剂量辐射后肿瘤组织的变化情况。方法通过肝细胞过氧化脂质(LPO)的测定、肝细胞谷胱甘肽过氧化物酶(DTNB)测定、肝细胞超氧化物歧化酶(SOD)活性测定,了解低剂量辐射对荷瘤小鼠肝细胞抗氧化酶的影响及合并大剂量辐射后肿瘤组织的变化情况。结果低剂量辐射可以诱导肝脏抗氧化酶升高,预先给予0.05 Gy、6 h后再施以大剂量X射线照射较单纯施用大剂量照射者肝细胞过氧化脂质(LPO)含量降低,谷胱甘肽过氧化物酶(GSH-Px),超氧化物歧化酶(SOD)活性增强。肿瘤组织病理表明,应用低剂量辐射,肿瘤组织内可明显的毛细血管增生,浸润淋巴细胞(TIL)数增加。结论大剂量照射肿瘤组织前采用低剂量全身照射对机体正常组织有保护作用,同时也有利于对肿瘤组织的杀伤作用。
作者 刘蕴光
机构地区 吉林省人民医院
出处 《中国自然医学杂志》 CAS 2006年第3期220-221,共2页 Chinese Journal of Natural Medicine
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