摘要
细胞外ATP(ATPo)和腺苷是细胞内外重要的信号分子,对包括肿瘤细胞在内的多种组织细胞具有细胞毒和诱导凋亡的作用。腺苷及其受体诱导细胞凋亡的机制主要涉及腺苷酸环化酶(AC)、cAMP、Ca2+等。ATP的诱导细胞凋亡作用与多个嘌呤受体有关,包括P2X1、P2X2、P2X7、P2Y1、P2Y2等,进一步的作用机制可能涉及FasL/FasR死亡受体、T细胞受体(TCR)、bcl-2和bax的基因调控等。
Extracellular adenosine triphosphate （ATP） and adenosine are important signaling molecules in both intracellular and extracellular microenviroments of cells. They exert cytoxic and apoptotic effects in some tissues such as tumor. The proapoptotic mechanisms of adenosine and its receptors are involved in Adenylyl cyclase（AC）, cAMP, Ca^2＋, etc. Apoptosis induced by ATP is as sociated with several purinergic receptors including P2X1, P2X2, P2X7, P2Y1, P2Y2, et al, it is also involved in FasL/FasR, T cell receptor（TCR）, and gene regulations of bcl-2 and bax.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2006年第9期1029-1034,共6页
Chinese Pharmacological Bulletin
基金
河北省科技攻关项目资助项目(No20042761317)
关键词
腺苷三磷酸
腺苷
嘌呤受体
细胞凋亡
adenosine triphosphate
adenosine
apoptosis
purinergic receptors
