摘要
目的研究新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的的毒杀活性。方法采用WHO生物测试法测定吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀活性。结果12种新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀作用有明显的差异,化合物4.4、4.5和4.6的毒杀作用明显高于其它化合物。结论12种新型吡啶类鬼臼毒素衍生物对3龄初淡色库蚊幼虫毒杀作用的差异可能与结构上的差异有关。
Objective The bioactivity of twelve novel pyridine ring derivatives of podophyllotoxin were tested against 3rd instar larvae of Culex pipiens pallens. Methods Using WHO bioassay method. Results From twelve novel pyridine ring derivatives ofpodophyllotoxin, three compounds 4.4, 4.5 and 4.6 have more higher toxicities than others, and the LC50 were 1.66, 3.96 and 1.54 mg/L respectively. Conclusion Based on the data obtained in this investigation, it is possible that the dissimilarity in the structure of the analogues leads to their different bioactivity.
出处
《实验动物与比较医学》
CAS
2006年第3期144-147,共4页
Laboratory Animal and Comparative Medicine
基金
国家自然科学基金资助项目(批准号:30371169)
关键词
吡啶类鬼臼毒素
淡色库蚊
植物源杀虫剂
Pyridine ring derivatives ofpodophyllotoxin
Culex pipiens pallens
Botanical insecticide
