摘要
目的:观察中药溃结露灌肠对溃疡性结肠炎(UC)患者血清超氧化物歧化酶(SOD)和丙二醛(MDA)的影响。方法:选择活动期UC患者38例,应用溃结露灌肠治疗2周后,测定患者血清SOD和MDA的含量,并与正常对照组30例作对比。结果:UC患者血清MDA浓度明显高于正常对照组(P<0.01),而SOD含量明显低于正常对照组(P<0.01);经溃结露治疗后,临床症状明显缓解,有效率为86.1%;血清MDA较治疗前明显降低(P<0.01),SOD则较治疗前明显升高(P<0.01)。结论:氧自由基损伤是UC发病过程的一个重要因素,溃结露可以降低UC患者的自由基水平,具有明显的疗效。
To observe effects of enema of Kuijielu on serum SOD activity and MDA content m the patient ot active ulcerative colitis. Methods：38 eases were treated with Kuijielu Enema for 2 weeks,and serum SOD and MDA were determined before and after treatment,with 30 healthy persons used as controls. Results ：Serum MDA level in the patient of active ulcerative coitis before treatment was significantly higher and the SOD activity was significantly lower than those in the control group（both P（0.01）; After treatment, clinical symptoms significantly improved with an effective rate of 86. 1%, meanwhile, serum MDA content significantly decreased （P〈0. 01 ） and SOD activity significantly increased （P〈0. 01 ）. Conclusion：Injury of free radicals is an important factor in the attack of ulcerative colitis,and Kuijielu can decrease free radical level in the patient of ulcerative colitis and has obvious therapeutic effect on ulcerative colitis.
出处
《中医杂志》
CSCD
北大核心
2006年第9期668-669,共2页
Journal of Traditional Chinese Medicine
