摘要
目的研究异丙酚、咪唑安定分别复合芬太尼麻醉用于无痛电子支气管镜检查的效果及安全性。方法选择300例电子支气管镜检查患者,随机分成3组,A组异丙酚复合芬太尼麻醉、B组咪唑安定复合芬太尼麻醉、C组(对照组)静脉注射生理盐水10ml;观察每组的镇静效果及检查前、检查中(给药后)及完全清醒的血压、心率、呼吸、血气分析。结果镇静结果显示A、B组均无痛苦及任何不适应感觉,但B组呛咳(42例)、躁动(56例)、检查中断(39例)的发生率明显高于A组(11例,13例,11例)(均P<0.01);C组均感觉恐惧及痛苦;检查中A、B两组血压、呼吸呈下降趋势,心率由检查前的增快降至正常水平,C组血压、心率明显升高。3组血压、呼吸、心率比较差异具有统计学意义(P<0.01),3组检查前后氧分压(PaO2)均明显下降,3组比较差异具有统计学意义(P<0.01),但二氧化碳分压(PaO2)、pH值在3组中有轻度升高趋势,仅B组PaO2在检查前后有统计学意义(P<0.01)。结论异丙酚复合芬太尼麻醉在无痛支气管镜检查中减少了躁动、呛咳、屏气引起的检查中断,镇静效果优于咪唑安定,相对安全、无痛苦,值得荐用。
Objective To study the effects and safety of propofol and midazolam respectively compounded with fentanyl anaesthetic used in painless electronic bronchial lens. Methods Three hundred patients chosen by the electronic bronchial lens were divided into three groups randomly. The patients in group A were treated with propofol compounded with fentanyl anaesthetic, while those in group B treated with midazolam compounded with fentanyl anaesthetic, and group C（contrasting group） treated with saline injection 10 ml into the vein. The mitigative effect in each group was detected, and their blood pressure, heart rate, respiration, oxygen saturation and blood gas were checked before the examination, during the examination（after taking the medicine）, and when the patients were completely conscious. Results There was no pain or discomfort to the patients in both group A and B. While the phenomena of choking and coughing （42 cases）, dysphoria （56 cases）, and breaks during examination （39 cases） appeared much more in group B than in group A（11 cases,13 cases,11 cases） （all P 〈0.01）. The patients in group C all sensed fear and pain. During the examination, blood pressure,respiration tended to go down in patients of group A and B. The accelerating heart rate before the examination descended to normal level. While there was a conspicuous increase in blood pressure and heart rate in the patients of group C. For blood pressure,respiration and heart rate there were significant differences among three groups（ P 〈0. 01）. For partial pressure of oxygen in artery（PaO2 ）, there were significant decreases before and after the examination among three groups （all P〈0. 01）, but PaO2, pH value showed slight trend of increase,only group B showed significance in PaCO2 before and after examination（ P〈0.01）. Conclusion Propofol compounded with fentanyl anaesthetic in painless bronchial lens examination can reduce halts in the examination due to dysphoria, choking and coughing, and holding one�
出处
《临床荟萃》
CAS
北大核心
2006年第20期1455-1458,共4页
Clinical Focus
关键词
支气管镜检查
二异丙酚
安定药
实验室技术和方法
bronchoscopy
propofol
tranquilizing agents
laboratory techniques and procedures
