摘要
正电子发射型计算机断层显像(Positron Emission Tomography,简称PET)是用解剖形态学方式进行功能、代谢和受体显像并提供分子水平信息的一项前沿医学科学显像诊断技术。它主要利用构成人体基本元素的超短半衰期同位素如氧(O)、氮(N)、碳(C)、氟(F)等示踪生命的基本物质代谢过程,具有灵敏度高、创伤性小等特点,可在分子水平上反映人体生理或病理变化。目前临床常用的显象剂主要是氟脱氧葡萄糖(FDG),它主要反映人体葡萄糖代谢过程。PET在肿瘤学方面的临床应用可以追溯到20世纪80年代。早期的PET主要应用于不明确的孤立性肺部结节的诊断方面。随着其技术的不断完善、检查辅助药物制备成本下降和优越性的体现,PET的临床应用被逐渐推广至大肠、食管、乳腺和头颈部等肿瘤的诊断、分期和疗效监测、复发或残余病灶的检出等方面,本文就其在头颈部肿瘤中的应用予以综述。
Positron emission tomography （Positron Emission Tomography, i.e. PET in brief） is a technique of medical localization diagnosis in frontier science that conducts functional, metabolic and receptor visualization with anatomic morphology and provides information of molecular level. It mainly utilize the primary substance metabolism process of the hyper-short-half-life isotope, which compose the human essential elements, such as O, N, C and F, etc. It has the characteristics of high sensitivity and minor trauma and can reflect physiological or pathological changes of humans at molecular level, At present, the fluorodeoxyglucose （FDG）, a common developer used in clinical practice can mainly re- flect human metabolic process of glucose. The clinical application of PET in oncology can be traced back to 1980＇s. Early application of PET has mainly been in diagnosis of indefinite and solitary nodus of the lung. With consummation of the technology, decrement of cost for examining preparation of anciliary drugs and materialization of the superiority, the clinical application of PET were gradually extended to the diagnosis, staging and surveiliance of curative effects, as well as detection of relapse or residual foci for tumors in large intestine, esophagus, breast, and head and neck, ere.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第17期1018-1020,共3页
Chinese Journal of Clinical Oncology
基金
四川省医学重点学科建设项目基金资助(编号:20020807)
关键词
PET
头颈肿瘤
诊断
PET Head and neck tumor Diagnosis
