摘要
目的:探讨膀胱移行细胞癌患者TGF-β1水平测定及其临床意义。方法:采用酶联免疫吸附法检测膀胱癌患者血清、尿液中TGF-β1浓度。结果:膀胱癌患者血清TGF-β1水平显著高于正常对照,随病理分期、分级提高和肿瘤进展,膀胱癌患者血清TGF-β1水平呈下降趋势。患者尿液TGF-β1浓度显著低于正常对照,不同病理分期、分级之间差异无显著性。结论:血清TGF-β1水平增高可能是膀胱癌患者免疫功能受损的原因;尿液TGF-β1浓度降低可能导致肿瘤细胞增殖加速,成为膀胱癌复发的危险因素。
Objective To investigate the role of TGF-β1 in the occurrence and development of bladder transitional cell carcinoma. Methods The concentration of serum and urine TGF-β1 levels were measured in bladder cancer patients with ELISA technique. Results The serum TGF-β1 level in bladder cancer patients was significantly higher than that in normal controls. With the increasing in pathological stage, grade and tumor advancement, the serum TGF-β1 level in patients changed in a decreasing trend. The urine TGF-β1 level in patients was significantly lower than that in normal controls. The difference of urine TGF-β1 level in patients with different pathological stages and grades was not significant. Conclusion The elevated serum TGF-β1 level may be the cause of damaged cellular immune function in bladder cancer patients. The reduction of urine TGF-β1 level in patients can lead to the acceleration of tumor cell proliferation and may be the risk factor for tumor recurrence.
出处
《实用诊断与治疗杂志》
2006年第10期703-704,707,共3页
Journal of Practical Diagnosis and Therapy
