摘要
为研究固体二氧化氯消毒剂的杀菌性能及其毒性,采用载体浸泡定量杀菌试验和动物试验法,在实验室和现场进行了实验观察。结果,以含103.9 mg/L二氧化氯消毒剂水溶液对载体上大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌作用2.5 m in,平均杀灭对数值均>3.00。含2 mg/L二氧化氯作用10 m in,可使人工染菌水样中大肠杆菌下降为0 cfu/100 m l;温度、pH和有机物对该消毒剂水消毒效果影响不明显。用含103.9 mg/L二氧化氯的消毒液浸泡消毒作用10 m in,对餐具上大肠杆菌杀灭对数值均>3.00;物体表面擦拭消毒5 m in,对自然菌杀灭对数值均>1.00。在天然水库水中加入2 mg/L二氧化氯作用10 m in,可使天然水库水中大肠杆菌下降为0 cfu/100 m l。该二氧化氯小鼠经口毒性LD50>5000 mg/kg(体重),属实际无毒级;无蓄积毒性,无致微核作用。结论,固体二氧化氯消毒剂对细菌繁殖体和真菌杀灭效果较好,动物试验属于无毒级。
In order to study the germicidal efficacy and toxicity of solid chlorine dioxide disinfectant, carrier immersion quantitative germicidal test and animal test method were used to carry out laboratory and field experimental observation . Results： The average killing logarithm values of Esherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans on carriers exposed to the water solution containing chlorine dioxide disinfectant 103.9 mg/L for 2.5 min were 〉 3.00. The solution containing chlorine dioxide 2 mg/L with a 10 min contact time reduced E. coli in artificially contaminated water sample to 0 cfu/100 ml. The temperature, pH and organic substance did not obviously influence the efficacy of the disinfectant in disinfection of water. The killing logarithm value of E. coli on tableware immersed in the disinfectant solution containing chlorine dioxide 103.9 mg/L for 10 min was 〉 3.00 and the killing logarithm of the natural bacteria on surface wiped with the disinfectant for 5 min was 〉 1.00. Adding 2 mg/L chlorine dioxide to the natural reservoir water and allowing it to dwell for 10 min could reduce E. coli in the natural reservoir water to 0 cfu/100 ml. The mouse oral toxicity LD50 of chlorine dioxide was 〉 5000 mg/kg（bw） , belonging to essentially non -toxic class. It had no cumulative toxicity and did not induce micronucleus formation. Conclusion： The solid chlorine dioxide disinfectant has relatively good efficacy in killing vegetative forms of bacteria and fungi and belongs to non - toxic class in animal test.
出处
《中国消毒学杂志》
CAS
北大核心
2006年第5期433-435,共3页
Chinese Journal of Disinfection
关键词
二氧化氯
影响因素
杀菌效果
毒性
细菌繁殖体
真菌
chlorine dioxide
influencing factor
germicidal efficacy
toxicity
vegetative form of bacteria
fungus
