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拉米夫定与阿德福韦先后治疗慢性乙型肝炎的近期疗效观察 被引量:2

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摘要 目的探讨拉米夫定停药后乙型肝炎复发的治疗方法。方法对76例慢性乙型肝炎患者经拉米夫定治疗48周达到停药条件而停用后病情复发者,患者自愿继续服用阿德福韦者37例,给予阿德福韦酯片10mg口服,每日一次,连用6个月。另外39例停用拉米夫定后未接受任何治疗者为对照组。结果两组治疗后临床症状、体征、血生化指标、HBeAg转阴及HBeAg/抗-HBe血清转换无明显差异(P>0.05),而治疗组HBVDNA转阳者与对照组比,差异非常显著(P<0.01)。结论阿德福韦应用于拉米夫定治疗后复发的慢性乙型肝炎,对HBVDNA持续阴转疗效较好,表明阿德福韦有较好地抑制乙型肝炎病毒的作用。
出处 《实用肝脏病杂志》 CAS 2006年第5期298-299,共2页 Journal of Practical Hepatology
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