摘要
目的探讨瘦素水平与早期自然流产的关系。方法检测25例正常早孕妇女(对照组)及30例原因不明自然流产病人(研究组)的血清、绒毛和蜕膜组织中瘦素及β人绒毛膜促性腺激素(-βhCG)的水平。结果研究组及对照组胎盘绒毛组织中瘦素水平均有较高表达,但对照组瘦素水平高于研究组(H=15.26,P<0.01),蜕膜组织无瘦素表达。对照组血清瘦素和-βhCG水平明显高于研究组(t=9.493、5.356,P<0.01);且两者呈正相关(r=0.776,P<0.05)。结论血清和胎盘绒毛组织中瘦素水平降低可能是发生自然流产的原因之一。
Objective To investigate the relationship between leptin and early spontaneous abortion. Methods The levels of leptin and β-hCG in serum, syncytiotrophoblast and decidua in 30 early spontaneous aborters （control group） and 25 healthy women with early pregnancy （research group） were determined. Results The levels of leptin in syncytiotrophoblast were high in both spontaneous aborters and normal gravida,but it was higher in the controls （H= 15.26,P〈0.01） ,no leptin was expressed in deeidua. The levels of serum leptin and β-hCG were significantly lower in spontaneous aborters than in normal gravida （t=9. 493,5. 356;P〈0. 01）,showing a positive correlation between the two markers（r=0. 776, P〈0. 05）. Conclusion Decrease of leptin in serum and syncytiotrophoblast may be one of the reasons of early spontaneous abortion.
出处
《青岛大学医学院学报》
CAS
2006年第4期350-351,353,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
流产
自然
瘦素
绒毛膜促性腺激素
Β亚单位
人
abortion, spontaneous
leptin
chorionic gonadotropin, beta subunit, human
