摘要
建立了HPLC法测定马来酸氯苯那敏片含量。采用C18柱,流动相为甲醇-0.05mol/L磷酸二氢钾溶液(50∶50),检测波长264nm。结果表明马来酸氯苯那敏在2～40μg/ml范围内线性关系良好,平均回收率为99.2%,RSD为0.71%。并复核验证了部分文献报道的含量测定方法中存在的问题。
A HPLC method was established for the determination of chlorphenamine maleate tablets. A C18 column was used with the mobile phase of methanol -0.05mol/L potassium dihydrogen phosphate solution （50：50）, at the detection wavelength of 264nm. The calibration curve of chlorphenamine maleate was linear in the range of 2 - 40μg/ml. The average recovery was 99.2%, with RSD of 0.71%. The errors in some literatures of determination were corrected.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2006年第9期627-629,共3页
Chinese Journal of Pharmaceuticals
