摘要
目的:探讨联合吸入糖皮质激素与长效β2激动剂对慢性阻塞性肺疾病(COPD)的治疗作用。方法:急性加重期COPD病人60例,给予吸入布地奈德干粉400μg,2次/d,同时吸入福莫特罗干粉9μg,2次/d。观察1月、3月、6月,并测定痰液中炎性介质白细胞介素(IL-8)的量。结果:肺功能治疗前后有明显提高(P<0·05)。呼吸症状均有所改善,尤其是喘息症状改善明显;痰中IL-8治疗后明显下降(P<0·05)。结论:联合吸入糖皮质激素与长效β2激动剂对COPD患者的肺功能、自觉症状均有改善,痰中IL-8水平降低,可能与糖皮质激素加强了对气道炎症的作用有关。
Objective：To investigate the therapeutic effect of inhaled corticosteroid combined with longacting β2 agonist（LABA） on patients with chronic obstructive pulmonary disease（COPD）. Methods： 60 COPD patients in actue aggravation were received routine treatment（inhaling budesonide 400μg bid and formoterol 9μg bid）. At the following three time points： 1m, 3m, 6m, pulmonary symptom and lung function were investigated respectively. Level of interleukin-8 from inflamatory cell in sputum was measured before and after treatment. Results： After treatment, the observed index and the lung function were obviously improved（P〈0. 05）. Level of Il-8 in sputum significantly decreased after treatment（P〈0. 05）. Conclusion： The patients inhaling corticosteroid and LABA could improve the lung function with COPD. It may play a role on patients with COPD by way of reducing the airway inflamatory reaction. Chronic obstructive pulmonary disease; Corticosteroid;
出处
《河北北方学院学报（医学版）》
2006年第5期34-35,共2页
Journal of Hebei North University:Medical Edition
