摘要
目的研究整合素α_5β_1和血管内皮生长因子(VEGF)在非小细胞肺癌(N SCLC)组织中的表达及其与临床病理特征的关系。方法用免疫组化法检测53例N SCLC患者病灶组织及12例正常肺组织中α_5β_1及VEGF的表达情况。结果α_5β_1、VEGF在N SCLC组织中的表达(58.49%、75.47%)均明显高于正常肺组织(16.67%、25.00%),差异均有统计学意义(P<0.05)。α_5β_1β表达与病理分级呈负相关,与淋巴结转移、临床分期呈正相关;VEGF表达与临床分期、淋巴结转移呈正相关。结论整合素α_5β_1和VEGF高表达促进了N SCLC的侵袭、转移,两者在N SCLC的发生、发展中可能起相互促进作用。
[Objective] To study the expression of integrin α5β1 and VEGF in non-small cell lung cancer （NSCLC） and its relationship with clinicopathological characteristics.[Methods] The expression of integrin α5β1 and VEGF was examined by immunohistochemistry technology in 53 cases of NSCLC and 12 normal lung tissues. [Results] The expression of integrin α5β1 and VEGF （58.49%, 75. 47%） in NSCLC tissues was significantly higher than that of normal lung tissues （16.67%,25.00%）,and the differences both had statistical significance （P〈0.05）. The expression of integrin α5β1 was positively correlated with clinical stage （P=0. 042） and lymph node metastasis （P=0. 020） and negatively correlated with pathological grade （P= 0. 031）. The expression of VEGF was positively correlated with clinical stage and lymph node metastasis （P = 0. 017 and 0. 002, repectively）. No correlation was observed between VEGF and the other clinicopathological factors （P〉0. 05）. [Conclusionsl Overexpression of integrin α5β1 and VEGF can contribute to the invasion and metastasis of NSCLC. The two factors may interact in the genesis and progress of NSCLC.
出处
《山东医药》
CAS
北大核心
2006年第25期16-18,共3页
Shandong Medical Journal
基金
山东省卫生科技计划项目(2003-104)
关键词
癌
非小细胞肺
整合素Α5Β1
内皮生长因子
血管形成
免疫组织化学
carcinoma, non-small-cell lung
integrin
vascular endothelial cell growth factor
angiogenesis
immunohistochemistry
