摘要
为探讨低强度Ｈｅ－Ｎｅ激光血管内照射（简称ＩＬＬＬＩ）在临床应用上的理论根据，对６０例不同类型冠心病（ＣＨＤ）患者进行低强度Ｈｅ－Ｎｅ激光血管内照射，观察反映血小板功能指标的血浆血栓素Ｂ２（ＴＸＢ２）、ＴＸＢ２／６－酮前列腺素Ｆ１α（ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α）和血小板膜颗粒糖蛋白（ＧＭＰ－１４０）的变化，并将同期口服阿司匹林治疗的１８例急性心肌梗塞（ＡＭＩ）患者的诸指标与其比较，结果显示ＩＬＬＬＩ治疗后ＡＭＩ组和不稳定性心绞痛组的血浆ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α及ＧＭＰ－１４０均显著降低，而阿司匹林治疗的ＡＭＩ患者血浆ＴＸＢ２及ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α虽也下降，但ＧＭＰ－１４０无明显变化，提示ＩＬＬＬＩ抑制血小板活化的功能超过阿司匹林。
Sixty patients with different types of coronary heart disease (CHD) were treated with intravascular low level laser irradiation therapy (ILLLI), 60 min per day for 10 days. The parameters of platelet activation including plasma thromboxane B 2(TXB 2), TXB 2/6 keto prostaglandin F 1α (6 keto PGF 1α ) ratio and granule membrane protein (GMP 140) concentration were studied before and after ILLLI. In the same time we also investigated the parameters of platelet activation in 18 patients with acute myocardial infarction(AMI), who received aspirin 75mg qd for 10 days. The results revealved that ILLLI reduced plasma TXB 2, TXB 2/6 keto PGF 1α ratio and GMP 140 concentration in AMI and unstable angina groups significantly. The plasma TXB 2and TXB 2/6 keto PGF 1α ratio in AMI group with administration of aspirin were also decreased. However, before and after aspirin therapy there was no change in the plasma GMP 140. Our data suggests that ILLLI may inhibit platelet activation strongly in patients with CHD and rebalance the TXA 2 PGI 2 system. So that it might significantly decrease the incidence of angina pectoris and AMI. ILLLI is more energetic than administration of aspirin to inhibit the platelet activation in patients with CHD. Therefore, we would consider that ILLLI has a fovourable therapeutic effects in CHD, it is safely and with no adverse reaction.
出处
《中国激光医学杂志》
CAS
CSCD
1996年第2期98-102,共5页
Chinese Journal of Laser Medicine & Surgery
关键词
冠心病
血小板功能
阿司匹林
激光疗法
ILLLI, Coronary heart disease, Platelet activation, Aspirin
