摘要
目的通过建立动物的近视眼模型,观察近视眼发展期和恢复期屈光状态的改变。方法实验动物为2日龄SPF美国进口白种莱航鸡,用透明眼罩遮盖动物(A组和B组)的右眼进行单眼形觉视觉剥夺,遮盖后第21天检测双眼屈光状态和眼轴;继续饲养B组和对照D组,去遮盖后第21天检测双眼屈光状态和眼轴,并将实验组和对照组的数据进行统计学分析。结果遮盖21 d后A+B组左右眼屈光度平均差值(-28.38±6.72)D,差异有统计学意义;A组左右眼眼轴平均差值(1.47±0.37)mm,差异有统计学意义;去遮盖21 d后,B组左右眼屈光度平均差值(0.19±0.92)D,差异无统计学意义;B组左右眼眼轴平均差值(0.15±0.50)mm,差异无统计学意义。结论在形觉剥夺性近视眼的小鸡模型中,屈光度及眼轴有显著性改变,而在去遮盖后又恢复至正常水平。
Objective To study the refractive change of the FDM chicks during the process of sclera remodeling. Methods 32 2-day-old white Leghorn chicks were divided into four groups. Form-deprivation myopia was induced by applying translucent plastic goggles attached on the right eyes group A and B. Untreated fellow eyes served as paired controls, and also normal controls group C and D were set. The goggles remained in place for 21 d, and all the eyes were checked up for refractive condition. Then killed the chicks of group A and C. Half of the treated chicks group B were raised for more 21 d. All the eyes were checked up for refractive condition and axial length. The data were analyzed by SSPS 11.0. Results Significant differences were detected in refraction and eye elongation of the covered eye and no significant differences were found after recovery from FDM between treated eye and normal control. Conclusion These data indicate that form-deprived myopia occurs with refractive change and axial elongation. And the myopia changes can be reversed after the recovery of form-deprived myopia.
出处
《首都医科大学学报》
CAS
2006年第4期553-555,共3页
Journal of Capital Medical University
