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Non-occupational lead exposure and hypertension in Pakistani adults 被引量:4

Non-occupational lead exposure and hypertension in Pakistani adults
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摘要 Hypertension is one of the most prevalent diseases in the developed and developing countries. Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposure a study was carried out to determine if an association existed between low blood lead concentration and hypertension. In this study the effects of low-level exposure to lead on blood pressure were examined among 244 adults using atomic absorption spectrometer. For quality assurance purpose certified reference materials i.e., Animal blood A-13, Bovine liver 1577 and cotton cellulose V-9 from IAEA (International Atomic Energy Agency) and NIST (National Institute of Standard Technology) were analyzed under identical experimental conditions. The mean age of hypertensive adults was 52 years (range 43-66). The mean values of systolic and diastolic blood pressure were (209±11.7) (range 170-250) and (117±3.9) (range 105-140) mmHg respectively. Blood lead concentration ranged from 78-201 μg/L with a mean of 139 μg/L and 165-497 μg/L with a mean of 255 μg/k in normal and hypertensive adults respectively. Increase in systolic blood pressure was significantly predictive with increase in blood lead levels. Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure. 高血压是最流行的疾病在之一发展;发展中的国家。基于长历史的协会;在铅暴露的底层的血压效果的挑衅性的调查结果研究被执行决定一个协会是否在低血铅集中之间存在;高血压。在这研究,到血压上的铅的低级暴露的效果用原子吸收分光计在 244 个成年人之中被检验。为证明的优秀保证目的引用材料即,动物血 A-13,牛的肝 1577;从国际原子能机构(国际原子能机构) 的棉花纤维素 V-9;NIST (标准技术的国家研究所) 在相同试验性的条件下面被分析。高血压的成年人的吝啬的年龄是 52 年(范围 43 ~ 6 6 ) 。吝啬的价值收缩;心脏舒张的血压是(209 ± 1 1.7 )( 范围 170 ~ 2 50 ) ;(117 ± 2 .9 )( 范围 105 } 140 ) mmHg 分别地。血铅集中从 78 ~ 2 有 139 μ g /L 的一个平均数的 01 μ g /L;165 ~ 4 有在正常的 255 μ g /L 的一个平均数的 97 μ g /L;高血压的成年人分别地。收缩血压的增加随血铅层次的增加是显著地预兆的。身体集体索引(BMI ) ;包括全部的胆固醇的类脂化合物侧面,低密度脂蛋白胆固醇,高密度脂蛋白胆固醇;甘油三酸酯与血压相关。
出处 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2006年第9期732-737,共6页 浙江大学学报(英文版)B辑(生物医学与生物技术)
关键词 HYPERTENSION Lead exposure Biochemical parameters Body mass index 高血压 照射性铅 生化参数 体质指数 巴基斯坦人
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  • 1Sufen Shang,Wang Hong.Flame atomic absorption spectrometry using a microvolume injection technique for the determination of Cu, Zn, Ca, Mg and Fe in whole blood from healthy infant and mother ears[J].Fresenius’ Journal of Analytical Chemistry.1997(7) 被引量:1
  • 2A. Brockhaus,I. Freier,U. Ewers,E. Jermann,R. Dolgner.Levels of cadmium and lead in blood in relation to smoking, sex, occupation, and other factors in an adult population of the FRG[J].International Archives of Occupational and Environmental Health.1983(2) 被引量:1

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