摘要
对20例隐球菌性脑膜炎患者进行分析,所有患者入院前均曾误诊1～4种不同的疾病,其中以误诊为结核性脑膜炎和病毒性脑炎频率最高。采用二性霉素 B、氟康唑单用或与氟胞嘧啶合用治疗,可评价疗效的15例患者中,痊愈10例(66.7%),好转2例(13.3%),死亡3例(20%),总有效率80%,复发率10%。研究结果表明:前期治疗采用二性霉素 B 间断鞘内注射与氟康唑静脉滴注合用,后期治疗应用氟康唑或伊曲康唑口服,可能是治疗隐球菌脑膜炎值得尝试的新途径。
This paper reports 20 patients with cryptococcal meningitis,which were misdiagnosed before anti-fungal therapy,and the majority of them was diagnosed as tuberculous meningitis or viral meningitis.These patients were treated either with amphotericin B or fluconazale alone,or in combina- tion with flucytosine respectively,of the 15 patients could be evaluated,10 were cured(66.7%),2 im- proved(13.3%),3 died(20%),1 relapsed(10%).The mortality rate among the under age group and the aged group was significantly higher than that of the adult group(71.4% vs 23%).It is the authors' experience that in the early stage intrathecal amphotericin B combines with intravenous fluoconazole and changes to oral fluconazole or itraconazole in the later stage may be a valuable approach for cryptococcal meningitis.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1996年第5期324-326,共3页
Chinese Journal of Dermatology
