摘要
目的:观察血管紧张素转换酶抑制剂(ACEI)类药物对原发性高血压患者纤溶功能的影响。方法:对31例高血压患者应用ACEI类药物卡托普利治疗前后情况进行比较,检测收缩压(SBP)、舒张压(DBP),观察超声心动图。检测血肾素(PRA)、血管紧张素Ⅱ(ATⅡ)、醛固酮(ALD)、组织型纤溶酶原激活物(t-PA)、内皮细胞型纤溶酶原激活物抑制剂(PAI-1)活性和含量。结果:治疗后SBP、DBP较治疗前均下降,差异有统计学意义(均P<0.01),左室射血分数、ALD及PRA治疗前后比较差异无统计学意义(均P>0.05),治疗后ATⅡ下降,PAI-1含量降低,tPA/PAI-1(活性)比值升高,差异有统计学意义(P<0.05或P<0.01)。PAI活性与ATⅡ正相关(r=0.576,P<0.01),与ALD、DBP正相关(r=0.451,r=0.430,均P<0.05)。tPA与各项指标均无关。结论:ACEI对纤溶功能的影响是有利的,能改善高血压患者存在的内源性纤溶功能紊乱。
Objective： To study the effects of angiotensin converting enzyme inhibitors （ACEIs） on fibrinolysis in patients with essential hypertension. Methods： Examinations of systolic and diastolic blood pressure （SBP, DBP）, echocardiography, renin, angiotensin Ⅱ （AT Ⅱ ）, aldosterone （ALD）, plasminogen activator inhibitor （PAI-1） and tissue-type plasminogen activator （t-PA）were performed before and after the treatment of captopril in 31 patients with essential hypertension. Results： SBP and DBP were lower after the treatment than that before the treatment, and there was a significant difference （P 〈 0.01）. There was no significant difference in left ventricular ejection fraction, ALD and PRA pre- and post-treatment （P 〉 0.05）. The level of AT Ⅱ and PAI-1 after the treatment were lower than that before the treatment, and there was a significant difference （P 〈 0.01）. The ratio of PA / PAI-1 （activity） after the treatment was higher than that before the treatment, and there was a significant difference （P 〈 0.05）. There was a positive correlation between the activity of PAI-1 and the level of AT Ⅱ （r = 0.576,P 〈 0.01）. There was a positive correlation between the activity of PAI-1 and the level of ALD （r = 0.451, P 〈 0.05） and DBP （r = 0.430, P 〈 0.05）. The level of t-PA had no relationship with each parameter. Conclusion： ACEIs has a beneficial effect to fibrinolysis, and can improve the endogenous fibrinolysis disturbance in patients with essential hypertension.
出处
《天津医药》
CAS
北大核心
2006年第9期622-624,共3页
Tianjin Medical Journal
基金
天津市自然科学基金资助项目(项目编号:013612011)
