摘要
烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性傅焕建,朱莉亚,林紫云(中国医学科学院,中国协和医科大学药物研究所,北京100050)高血压流行病学的调查表明[1],我国每年至少有95万以上高血压病人,所以高血压病是一类常见病,多发病。目前临床应用的...
Eighteen nicotinamides(I1~12)and pyridylacrylamides(I11~5)have beensynthesized. All synthesized amides were submitted to phannacological screening and 0.1um·L-1(10-7M)-noradrenaline induced contraction of the rat aortic strip was taken aS criterion,The amidesI3,4 and II1,2 showed more potent vasodilating activity than compounds 112.13 and II3.4.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第9期715-720,共6页
Acta Pharmaceutica Sinica