摘要
采用动物实验和病理组织学方法研究了一种中药免疫增强合剂对免疫器官的保护作用。结果表明，环磷酰胺、氟尿嘧啶和氢化可的松联合化疗可引起脾白髓容量（２４．８６±１０．５１％）、胸腺淋巴细胞容量（３０．５７±１０．３７％）和骨髓造血组织容量（２５．３３±１７．２４％）以及脾指数（４．６０±０．２０ｍｇ／ｇ（ｗｅｉｇｈｔ））和胸腺指数（１．３２±０．２８ｍｇ／ｇ（ｗｅｉｇｈｔ））明显降低。与此相比，在化疗后使用该中药合剂可以明显地提高脾白髓容量（６６．００±２．８３％）、胸腺淋巴细胞容量（６７．００±６．０１％）和骨髓造血组织容量（８１．００±５．０３％）以及脾指数（８．１８±２．９０）和胸腺指数（１．７９±０．２６）。在化疗前使用该合剂的小鼠各项指标均明显高于化疗对照组（Ｐ＜０．０５）。结果提示该中药合剂具有对抗化疗药物造成造血组织、脾白髓和胸腺淋巴细胞的损伤作用，同时也可促进化疗损伤的恢复。
The protective effect of a mixture of Traditional Chinese medicine on the immune organs of mice were studied.The results showed that the federal chemotherapy with cyclophosphamide, fluorouracil and hydrocortisone could decrease the content of the splenic white pulp(CSWP,24.86±10.51%),lymphocytes of the thymus(CLT,30.57±10.37%),and the hematopoietic tissue of marrow(CHTM,25.33 ±17. 24%),and lower the index of spleen(IS,4.60±0. 20 mg/g)and thymus(IT,1. 32±0. 28 mg/g).Significant increasing of C3WP(66.00±2.83%),CLT(67.00±6.01%),CHTM(81.00±5.03%),IS(8.18±2.90) and IT(1.79±0.26)were demonstrated in the chemotherapeutic mice fed with this mixture prechemotherapy and post-chemotherapy compared with the chemotherapy control group ( P <0.01).The effects of this mixture on the immune organs were discussed.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1996年第6期374-376,共3页
Chinese Journal of Immunology
基金
宁夏自治区科委资助课题
关键词
中药
免疫增强剂
骨髓
胸腺
脾脏
保护作用
Traditional Chinese medicine Bone marrow Spleen Thymus Chemotherapy
