摘要
目的研究雷米芬太尼对无抽搐电休克(MECT)治疗心血管反应的影响。方法32例抑郁症患者随机分成对照组与雷米芬太尼组,每组16例。对照组采用丙泊酚1.5mg/kg静脉麻醉;雷米芬太尼组给予等量丙泊酚加1μg/kg雷米芬太尼静脉麻醉。全麻诱导后皆静注琥珀酰胆碱,待肌肉松驰后行MECT治疗。全程监测患者ECG、HR、MAP、SpO2,并观察记录患者癫痫发作时间、自主呼吸恢复时间、苏醒时间。结果MECT治疗后即刻、1、3min两组HR、MAP较麻醉前明显升高(P<0.05或P<0.01),但雷米芬太尼组明显低于对照组(P<0.05);自主呼吸恢复时间雷米芬太尼组略长于对照组(P<0.05),但均在10min以内;癫痫发作时间、苏醒时间、SpO2两组差异无显著意义。结论雷米芬太尼适合应用于MECT治疗麻醉并可明显抑制MECT引起心血管反应。
Objective To observe the effect of remifentanil on cardiovascular response to the modified electroconvulsive therapy. Methods Thirty-two patients with depression were randomly divided into two groups with 16 cases each. Anesthesia was induced with intravenous propofol 1.5 mg/kg in group C and 1 μg/kg remifentanil followed by 1. 5 mg/kg propofol in remifentanil group R. Succinylcholine 1mg/kg was administered before electroconvulsive therapy. ECG, HR, MAP, SpO2. the duration of seizure and apnea, and recovery were observed. Results HR, MAP at 0, 1, 3 min after electroconvulsive therapy in group R were significantly lower than those in group C. The time for recovery of respiration was later in group R than that in group C, but still shorter than 10 min. The duration of seizure and emergence from anesthesia was not statistically different between the two groups. Conclusion Remifentanil can be used for electroconvulsive therapy with reduced cardiovascular response.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第8期619-620,共2页
Journal of Clinical Anesthesiology
关键词
雷米芬太尼
电休克治疗
心血管反应
Remifentanil
Electroconvulsive therapy
Cardiovascular response
