摘要
目的:研究纤维调节素在大鼠和人类健康和牙龈组织中的分布与表达。方法:用免疫组织化学的方法研究纤维调节素在大鼠牙龈及人类健康和炎性牙龈组织中的分布。与之比较,I型胶原纤维在鼠磨牙牙龈组织中的分布也做了研究。结果:在大鼠牙龈中,纤维调节素分布在牙龈上皮基底上层,在腭侧牙龈结缔组织有强表达。I型胶原纤维也有类似的分布。比较而言,纤维调节素在颊侧牙龈结缔组织表达较弱。对于人类,纤维调节素在炎性牙龈结缔组织中表达明显,然而在健康牙龈结缔组织中表达较弱。结论:与Ⅰ型胶原纤维关系密切的纤维调节素在颊侧和腭侧牙龈中有差异性表达,并且在人类炎性牙龈组织中表达增强。
Objective： The aim of this study was to determine the distribution and expression of fibromodulin in adult rat gingival tissues and healthy and inflamed human gingiva. Methods： The distribution of fibromodulin in rat molar gingiva and human healthy and inflamed gingival tissue was studied by immunohistochemistry. To compare with fibromodulin, type Ⅰ collagen was also studied in rat molar gingiva. Results： In the adult rat gingiva, fibromodulin was distributed in the suprabasal gingival epithelium. Strong expression was noted in the palatal gingival connective tissues. A similar pattern of dis- tribution was seen for type Ⅰ collagen. In comparison, there was less strong staining for fibromodulin in buccal gingival connective tissues. In human gingival tissues, staining of fibromodulin was detected in the connective tissue of inflamed gingiva associated with both gingivitis and periodontitis; whereas, weak staining for this molecule was noted in healthy gingival connective tissues. Conclusion： Fibromodulin is differentially expressed within the buccal and palatal gingiva being primarily associated with type Ⅰ collagen in non - mineralized sites. In addition, fibromodulin showed an upregulation in inflamed human gingival tissues.
出处
《口腔医学研究》
CAS
CSCD
2006年第4期357-359,共3页
Journal of Oral Science Research
基金
教育部留学回国人员科研启动基金资助项目
