摘要
目的:探讨大剂量羟基喜树碱+阿霉素+5-氟脲嘧啶(5-FU)动脉灌注治疗晚期上颌窦癌的疗效。方法:30例晚期上颌窦癌随机分为2组,颞浅动脉灌注组15例,采用大剂量羟基喜树碱+阿霉素+5-FU进行颞浅动脉插管灌注;静脉滴注组15例,采用同样剂量作静脉滴注,对2组的疗效进行比较。结果:颞浅动脉灌注组完全缓解(CR)6例(40.0%),部分缓解(PR)7例(46.7%),总缓解率达86.7%;静脉滴注组CR 1例(6.7%),PR 6例(40.0%),2组缓解率差异有统计学意义(P<0.05)。结论:羟基喜树碱+阿霉素+5-FU行颞浅动脉插管灌注化疗是治疗晚期上颌窦癌较好的方法。
Objective： In order to investigate the therapy effect of the artery infuses with Hydroxycamptothecine＋ Adriamycin＋5-FU to treat the advanced maxillary sinus carcinoma. Methods： Thirty cases with ad- vanced carcinoma of the maxillary sinus were randomized to 2 groups, A group infuse with Hydroxycamptothecine＋Adriamycin＋5-FU by the tube in arteria temporalis superficialis, another group was given by vein drop with the same dose, carrying on the prospect contrast research. Results： Complete respone （CR） of the artery infuses was 40.0%, and partial respone（PR） 46.7%, the CR of other group was 6.7%, and PR was 40.0%. There was obvious difference between two groups. Conclusions： Infusing with Hydroxycamptothecine＋ Adrlamycin＋ 5-FU by the tube of temporalis superficialis artery has higher effect than the method of vein dropping. It is a good method to treat advanced maxillary sinus carcinoma by infusing with Hydroxycamptotheclne＋Adrlamycin＋5-FU by the tube of temporalis superficlalis artery.
出处
《新疆医科大学学报》
CAS
2006年第8期709-710,共2页
Journal of Xinjiang Medical University
关键词
上颌窦癌
化疗
动脉灌注
maxillary sinus carcinoma
chemotherapy
artery infuse
