摘要
目的：观察乳腺癌组织中Bubl表达概况,探讨Bubl蛋白在乳腺癌中表达水平及意义。方法：用免疫组化方法检测50例乳腺癌中Bubl蛋白的表达。结果：正常乳腺组织Bubl蛋白阳性表达率为84%,癌组织中阳性表达率为46%,两者差异有显著性(P＜0.05)。Bubl表达与癌组织分化、腑窝淋巴结转移、复发和转移有关(P＜0.05)。结论：Bubl蛋白表达异常是乳腺癌产生的机制之一,与乳腺癌的发生发展有关。
Objective： To observe the expression of Bub1 protein in breast cancer tissues and evaluate its clinical signifi cance. Methods; Immunohistochemical staining was used to evaluate Bub1 protein levels in a panel of 50 cases with breast cancer. Results： The positive rate of Bubl expression in normal and breast cancer tissues was 84% and 46%, respectively. There was significant difference between breast normal tissue and breast cancer tissue （P〈0.05）. Bub1 expression was related to the differentiation, lymph node metastasis, and recurrence of breast cancer （P〈（0.05）. Conclusion： Abnormal expression of Bub1 protein is one of the mechanisms responsible for breast carcinogenesis. It is related to initiation and progression of breast cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
2006年第8期758-760,共3页
Tumor
关键词
乳腺肿瘤
肿瘤复发
局部
肿瘤转移
免疫组化
基因
BUB1
Breast neoplasms
Neoplasm recurrence, local
Neoplasm metastasis
Immunohistochemistry
Genes, Bub1
