摘要
目的研究介入化疗栓塞对中晚期肺癌的近期疗效与毒副反应。方法68例肺癌患者给予支气管动脉造影明确其分支及肿瘤血供情况,超选至靶血管,先行局部化疗药物灌注[卡铂(CBP)/表柔比星(EPI)/5-氟尿嘧啶(5-Fu)等],后以明胶海绵进行栓塞,间隔4～6周再次作化疗栓塞,68例共行136次。结果68例大多供血丰富,二次介入治疗者肿瘤血供减少,治疗有效率(RR)为82.3%;临床受益(CBR)率97.0%,主要毒副作用是骨髓抑制,特别是粒细胞减少,与常规静脉化疗的毒副作用类似,未见其他严重的毒副反应。结论支气管动脉化疗栓塞术治疗中晚期肺癌有较佳的近期疗效与CBR率,但远期效果有待进一步研究。
Objective To analyze the short-term treatment effects and adverse effect on intermediate or advanced lung cancer by means of transbronchial arterial chemoembolization. Methods 68 patients were included in this study. First bronchial arteriography was performed to identify the tumor-feeding branch, and super-catheterize it. After CBP, EPI and 5-Fu was infused, embolization with gelatin sponge was carried out, chemoembolization was reperformed at 4～6 weeks intervals, 136 times of chemoembolization were done in 68 cases. Results The tumor blush of 51 patients stained obviously ,the feeding arteries with the second treatment decreased obviously. In 68 patients, the overall response rate was 82.3 %, the clinical beneficial rate was 97.0 %. The main side effect was myelosuppression, especially granulocytopenia, which was similar to that of conventional intravenous chemotherapy. No other severe adverse effect was seen. Conclusions Transbronchial arterial chemoembolization by selective tumor-feeding arteries catheterization has good short-term effect and clinic beneficial rate in the treatment of intermediate or advanced lung cancer, but the long-term treatment effects will be studied in the future.
出处
《肿瘤研究与临床》
CAS
2006年第8期553-554,共2页
Cancer Research and Clinic
关键词
支气管动脉化疗栓塞
肺癌
Transbronchial arterial chemoembolization
Lung cancer
