摘要
用蒸气吸入性损伤犬模型,对其伤前、伤后呼吸和循环动力学的早期变化进行了观察比较,旨在为临床应用提供依据。结果发现:致伤后呼吸系统总阻力逐渐上升(3小时和4小时 P<0.05);呼吸系统总顺应性在伤后3小时,肺顺应性在伤后4小时均显著下降(P<0.05);在伤后2小时,心率非常显著地减少(P<0.01),心输出量显著降低(P<0.05)。提示蒸气吸入性损伤后,早期就发生呼吸和循环动力学的变化。早期检测这些指标,有助于及时诊治吸入性损伤。
Early changes in respiratory and circulatory dynamics before and after steam-inhalation injury were made in a dog model were studied.The results showed that the resistance of the respiratory system was significantly higher 3 hours and 4 hours post injury than that before injury(P<0.05),the compliances of both the lung 4 hours post-injury and the respiratory system 3 hours psot-injury signifi- cantly decreased(P<0.05),and the heart rate markedly lowered(P<0.01),and the cardiac output al- so decreased(P<0.05)2 hours after injury.It is suggested that the early changes in the respiratory and circulatory dynamics may be used as markers for the diagnosis and treatment of the inhalation injury.
基金
国家自然科学基金
关键词
吸入性损伤
呼吸力学
循环动力学
Inhalation injury
Respiratory dynamics
Circulatory dynamics
