摘要
目的比较不同厂家阿莫西林原料、胶囊、混悬剂中高分子杂质的含量。方法采用OhpakSB-802.5HQ(聚合基柱)高效液相凝胶色谱系统进行分离分析。结果21批阿莫西林样品中高分子杂质的测定结果均为1%以下。结论国产与进口阿莫西林中的高分子杂质含量无显著差异。
OBJECTIVE To develop a method for determination the high molecular impurities in amoxieillin to evaluate the quality of amoxieillin and its capsule or suspension. METHODS Determination of high molecular impurities using Ohpak SB-802.5HQ gel filtration chromatography was established. RESULTS 21 batehas of amoxieillin were analyzed. The contents of the high molecular impurities were all less than 1%. CONCLUSION Results of analysis showed there were no significant differents in the contents of impurities between domestic and imported.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2006年第4期326-327,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
阿莫西林
高分子杂质
凝胶色谱
amoxieillin
high molecular impurities
gel filtration chromatography
