摘要
目的了解山莨菪碱（654—2）、开搏通、立其丁、多巴胺、硝苯地平对肾综合征出血热（HFRS）患者肾功能的影响，为临床选择改善肾功能的药物提供依据。方法共选择474例HFRS患者，入院后随机分为654—2组、开搏通组、立其丁组、多巴胺组、硝苯地平组和对照组，每组各79例。对照组仅给予综合疗法，其余各组均在综合治疗的基础上分别加用上述药物。结果654—2组、开搏通组、立其丁组、多巴胺组、硝苯地平组在尿蛋白消失时间、BUN复常时间、＆一微球蛋白复常时间、少尿期发生率、少尿期和多尿期持续时间等方面均优于对照组，尤以开搏通组和立其丁组最为明显（P〈0．05，0.01或0．001）。结论654—2、开搏通、立其丁、多巴胺和硝苯地平能促进HFRS患者的肾功能恢复，而以开搏通和立其丁为优。提示HFRS患者可常规应用654—2、开搏通、立其丁、多巴胺与硝苯地平；对于重症患者，可联合应用2～3种上述药物。
Objective It is to evaluate the effects of anisodamine, captopril, regitine, dopamine, nifedipine on kidney function in hemorrhagic fever with renal syndrome （HFRS）, and to provide the bases for selecting drugs to improve renal function. Methods 474 patients of HFRS were selected and randomly divided into anisodamine, captopril, regitine, nifedipine, dopamine treatment groups and control group. 79 patients were in every group. Control group was given comprehensive treatment only. Every treatment group was given these drugs on the base of comprehensive treatment. Results The disapperarance of urine protein, the recovery of BUN and β2 - microglobulin, incidences of oliguric stage, and duration of oliguric stage in anisodamine, captopril, regitine, dopamine and nifedipine group were better than that in control group, especially in captopril and regitine groups （p〈 0.05;0.01 or 0. 001 ）. Conclusion The recovery of renal function of patients with HFRS can be promoted by anisodamine, captopril, regitine, dopamine and nifedipine, particularly with captopril and regitine. It prompts anisodamine, captopril, regitine, dopamine and nifedipine can use rule. For serious patients, it will be better to use combined regimens （two to three kinds of drugs）.
出处
《现代中西医结合杂志》
CAS
2006年第17期2315-2317,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
肾综合征出血热
山莨菪碱
开搏通
立其丁
多巴胺
硝苯地平
hemorrhagic fever with renal syndrome
anisodamine
captopril
regitine
nifedipine
dopamine
