摘要
观察原发性肝癌(Primary hepatic carcinoma,PHC)患者血清TGFβ1及IL-2、IL-12、TNF-α、IFNγ水平及与临床演变的关系。采用酶联免疫法测定。PHC患者血清TGFβ1和TNF—α水平显著高于正常对照(P= 0．014,P=0．0001),IFNγ、IL-2和IL-12低于正常对照(P=0．008,P=0．018,P=0．007);血清TGFβ1与TNF-α和IL-2呈负相关(P<0．05,P<0．01),IL-12与IFNγ和总胆红素(TBil)呈正相关(P<0．01,P<0．01);将PHC患者分成I～Ⅱa期和Ⅱb～Ⅲ期两组,Ⅱb～III期患者血清TGFα1、TNF—α水平高于I～IIa期患者(P<0．05),而IFNγ、IL-2和IL—12显著低于I～Ⅱa期患者(P<0．05)。提示PHC患者存在多种细胞因子异常,细胞因子网络失衡,尤其中晚期患者更为明显,这可能是肿瘤逃脱免疫监控,不断进展的原因之一。
To investigate the levels of serum TGf-β1, IL -2, IL - 12, TNFα and IFNγ in patients with primary hepatic carcinoma （PHC）. 50 cases of PHC were enrolled to this study. Compared with controls, TGF- β1, TNF- α level were significantly increased （P =0. 014, P =0. 0001 ） and the levels of IFNγ, IL -2 and IL - 12 were significantly decreased in patients with PHC （ P = O. 008, P = O. 018, P = O. 007 ）. TGF - β1 was negatively correlated with TNF - α （ r = - O. 350, P 〈 O. 05 ） and IL - 2 （ r = - O. 476, P 〈 0.01 ）, IL - 12 was positively correlated with IFN - γ （ r = O. 612, P 〈 0.01 ）, TBil （ r =0. 439, P 〈0. O1 ）. In Ⅱ b and Ⅲ stage of PHC, the concentration of TGF - β1 and TNF - α were higher than that in Ⅰ and Ⅱa stage （ P 〈 0. 05, P 〈 O. 05 ）, and the concentration of IFNγ, IL - 2 and IL - 12 were lower than that in I and Ⅱ a stage （P 〈 0.05, P 〈 0.05, P 〈0.05 ）. These data showed that cytokines levels were disordered in PHC patients, and the network of cytokines were imbalance, and anti - tumor immune function were inhibited, especially in medium - later period. It might be one of the causative factors of the tumor progress.
出处
《临床肝胆病杂志》
CAS
2006年第4期247-249,共3页
Journal of Clinical Hepatology
关键词
原发性肝癌
细胞因子
细胞因子网络
Primary hepatic carcinoma
cytokine
network of cytokines
