摘要
目的评价经肝动脉小剂量栓塞化疗(TACE)联合经皮乙酸注射(PAI)治疗巨块型肝癌的疗效。方法28例巨块型肝癌患者,首次行常规剂量TACE治疗,重复TACE治疗采用小剂量(10mg丝裂霉素与碘油乳化栓塞),术后1周CT复查,依据碘油的充盈状况,对碘油稀疏和缺损区域进行PAI治疗。观察其治疗后的生存率,肿块的变化及术后肝功能、α-FP、副反应情况。结果28例患者术后1a,2a,3a累积生存率分别为96.4%,78.6%,32.1%,全部患者的肿块缩小。结论小剂量TACE联合PAI治疗巨块型肝癌能明显提高患者的生存率,术后肝功能损伤小,副反应少。
Objective To study the efficacy of low dose transhepatic artery chemoembolization （TACE） combined with percutaneous acetic acid injection （PAI） in the treatment of massive hepatocellular carcinoma （MHCC）. Methods Twenty - eight patients with MHCC intially received the conventional doses of TACE and then received low dose TACE （mitomycin 10 mg plus lipiodol 10 -30 mL） as the repeated treatment. Re - examined CT seans were performed at a week after TACE. Based on filling state of lipiodol in the lesionS. PAIs were performed to fill the rarefaction or defect area of lipiodol. The survival rate, masses variation, hepatic function, a - FP and adverse effects in all patients were abserved after the treatment. Results The survival rate in 28 patients were 96.4 %, 78.6 % and 32.1 % at 1st, 2nd and 3rd year after the treatment, respectively. The diminution of masses were found in all patients. Conclusion Low dose TACE combined with PAI can elevate significantly the survival rate of patients with MHCC. There are no obviously hepatic damage and adverse effects related to the procedure.
出处
《实用医学影像杂志》
2006年第4期208-210,共3页
Journal of Practical Medical Imaging
基金
湖北省卫生厅立项项目(项目编号:JX2C14)
关键词
经肝动脉栓塞化疗
肝癌
经皮乙酸注射
生存率
Transhepatic artery chemoembolization
Hepatocellular carcinoma
PAI
Survival rate
